The use of high-resolution bright-field microscopy is essential for cellular-scale biological research, but this technique has limitations due to low image contrast. Using dyes on the sample can ...

Researchers at University of Tsukuba have achieved high-resolution visualization of cellular organelles, such as nuclei and mitochondria, using an external apodized phase contrast (ExAPC) microscope.

Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to innovations in expansion microscopy. The advancements could help provide future insight into ...

Limited by the laws of physics, scientific discoveries and the advance of knowledge can be bound up in a series of slow proceedings. In microscopy, up until the early 21 st century, the diffraction ...

Scientists have introduced a microscopy technique that reveals a hidden layer of chemistry involving molecules that normally ...

Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...