Proteins play a key role in the life sciences - from basic research and biotechnological applications to the development and manufacturing of pharmaceuticals. Scientists at the Technical University of ...

A team of researchers has built a new protein sequencing workflow that pairs mirror proteases with deep learning software to read peptide sequences with far greater accuracy than previous methods.

Tedious, time-consuming, exasperating: Those are perhaps the three words that researchers use most commonly to describe protein purification. Proteins, and their little sisters the peptides, are among ...

Membrane proteins are the gateway to cells and are involved in many critical functions. Each membrane protein is unique, and their complexity makes it difficult to fit into a standardized expression ...

The team has further developed the method of chromatography. For this purpose, they have developed a light-sensitive molecular appendix that serves as an anchor for the target protein. It binds the ...

The rapid evolution of membrane chromatography and adsorption technologies has significantly impacted protein purification processes in the biopharmaceutical and biotechnology sectors. This integrated ...

The team, from biopharmaceutical company Regeneron, hopes their work will help researchers better understand protein-protein interactions during preclinical development of a drug. “Essentially, we ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Membrane proteins are crucial for numerous biological processes and serve as important drug targets. For decades, scientists have relied on detergents to extract membrane proteins from cell membranes ...

Vortex fluidic devices (VFDs) used with immobilized metal affinity chromatography (IMAC) have provided an effective, albeit cumbersome, way to separate His-tagged proteins. Researchers recently ...

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...