Ottawa Citizen on MSNOpinion

Deachman: Ottawa's quick fix for potholes ignores the larger problem

Have you heard about the Python 5000 — the goofily named one-person pothole-patching contraption the city has been using for ...

Eric Idle Celebrates 83rd Birthday: A Look at His Iconic Comedy Legacy

Idle turned 83 on March 29, marking another moment in a career that has spanned more than five decades and helped redefine modern comedy. Born in England in 1943, he rose to international fame as a ...
eLife

Negative-Valence Neurons in the Larval Zebrafish Pallium

This valuable work identifies a subpopulation of neurons in the larval zebrafish pallium that responds differentially to varying threat levels, potentially mediating the categorization of negative ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
AHA/ASA Journals

Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Netw…

BACKGROUND: Preeclampsia affects approximately 1 in 10 pregnancies, leading to severe complications and long-term health ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...