Abstract: The rapid advancement of scRNA-seq has generated massive data for cell type annotation. However, current automated annotation methods remain limited: most approaches separately model either ...

The accuracy of genomic annotation is crucial for subsequent functional investigations; however, computational protocols used in high-throughput annotation of open reading frames (ORFs) can introduce ...

Life’s story may stretch further back than scientists once thought. Some genes found in nearly every organism today were already duplicated before all life shared a common ancestor. By tracking these ...

Bradley Elliott receives funding from the Physiological Society, the British Society for Research on Ageing, the Altitude Centre, and private philanthropic individuals, and has consulted for industry ...

A person’s genes play a far greater role in likely lifespan than previously thought, according to a major new study published Thursday in the journal Science. Using data from human twin studies, an ...

Scientists have long believed that longevity is shaped by lifestyle choices; however, a new study reveals that genes may play a larger role in determining how long people live. Genetics accounts for ...

Three decades ago a famous study of Danish twins found that our genes “only moderately” influence how long we’re likely to live. Longevity, the authors estimated, was about 25 percent heritable, ...

A new CRISPR breakthrough shows scientists can turn genes back on without cutting DNA, by removing chemical tags that act like molecular anchors. The work confirms these tags actively silence genes, ...

The tool integrates de novo detection of NLR loci at the genome level with targeted genome reannotation, and systematically reconciles these results with existing annotations to produce a ...

Amy Lindberg spent 26 years in the Navy and she still walked like it—with intention, like her chin had someplace to be. But around 2017, her right foot stopped following orders. Lindberg and her ...